Potassium Tert-Butoxide 20% in THF

Potassium tert-butoxide, is a widely used strong base and reagent in organic chemistry. It is obtained by reacting potassium hydroxide with tert-butanol, resulting in the chemical formula KOtBu. This white or offwhite crystalline solid demonstrates high solubility in polar solvents like alcohols, ethers, and dimethyl sulfoxide (DMSO). As a strong base, KOtBu finds primary application in deprotonation reactions within organic synthesis. It serves as a nucleophilic catalyst and strong base in various reactions, including, elimination, and condensation reactions. Its versatility allows it to promote reactions such as dehydrohalogenation, aldol condensation, Claisen condensation, and the Williamson ether synthesis. Within the pharmaceutical industry, KOtBu plays a pivotal role as a reagent in diverse organic synthesis processes. Its basicity and nucleophilicity make it an invaluable tool for the preparation of active pharmaceutical intermediates, enabling the creation of essential compounds in pharmaceutical research and development with different activities like antineoplastic, anti-hypertensive, neuroprotectant, anticoagulant, antihistaminic, antibacterial.